SPINAL TOLERANCE AND DEPENDENCE: SOME OBSERVATIONS ON THE ROLE OF SPINAL N-METHYL-D-ASPARTATE RECEPTORS AND PHOSPHORYLATION IN THE LOSS OF OPIOID ANALGESIC RESPONSES

The continuous delivery of opiates can lead to a reduction in analgesic effects.In humans, as in other animals, some component of this change in sensitivity seems likely to have a strong pharmacodynamic component.Such loss of effect, deemed to be tolerance in the present article, can be readily demonstrated in animals with repeated bolus and contin

This paper presents an evaluation of a system aiming at estimating water depths on a road surface.Using accelerometers, the system records the vibrations of a wheel arch liner due Pediatric Suncare to impacts of water droplets.The system setup, including the location of the accelerometers on a wheel arch and the data acquisition, is described.Tests

With the aggravation of social aging and the increase in work intensity, the prevalence of spinal degenerative diseases caused by intervertebral disc degeneration(IDD)has increased yearly, which has driven a heavy economic burden on patients and society.It is well known that IDD is associated with cell damage and degradation of the extracellular ma

This study presents the results of an experiment in which the effect of addition of a yeast culture (Saccharomyces cerevisiae, Strain 47) on rumen fermentation was studied in thirty-six dairy cows of Holstein breed.The animals were divided into one control and five experimental groups.Each group involved 6 individuals.The animals received a diet co

Transporters are dynamic membrane proteins that are essential to the physiology of cells.To function, transporters must cycle between various conformational states, so to understand their mechanistic details, it is critical to characterize how their structure changes during the transport cycle.One approach to studying the dynamics of transporters t